Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Biased paternal transmission of TRH variant to female Down syndrome probands: possible correlation with low breast cancer frequency.

The International journal of biological markers - 24 Feb 2015

Dey Arpita, Chatterjee Arpita, Maiti Atanu, Mukherjee Nupur, Sinha Swagata, Panda Chinmay K, Mukhopadhyay Kanchan

Abstract excerpt

Thyroid malfunction is more common in individuals with Down syndrome (DS) than in the general population. It has been hypothesized that thyroid may influence cancer risk. Individuals with DS are at greater risk of developing leukemia than the general population, while solid tumors especially breast cancer (BC) are rare. BC patients have higher levels of circulating thyroid-stimulating hormone (TSH) and prolactin...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Breast Neoplasms
Share to Child

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Child, Preschool

Share to Down Syndrome

Share to Gene Frequency

Share to Genetic Association Studies

Share to Infant

Share to Young Adult

Source

Identifiers

PMID: 25362934
DOI: 10.5301/jbm.5000121

Genes

TRH
PRL

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Biased paternal transmission of TRH variant to female Down syndrome probands: possible correlation with low breast cancer frequency.PMID 25362934Read ↗

Identification of maternal risk factors for having Down syndrome cases in JordanSemantic proximity Read ↗

Meta-Analysis of DNA Methylation Datasets Shows Aberrant DNA Methylation of Thyroid Development or Function Genes in Down Syndrome.Semantic proximity Read ↗

Potential contribution of SIM2 and ETS2 functional polymorphisms in Down syndrome associated malignancies.Semantic proximity Read ↗

MTHFR gene polymorphism and associated nutritional deficiency in the etiology and pathogenesis of Down syndromeSemantic proximity Read ↗

Methylenetetrahydrofolate reductase polymorphisms C677T and A1298C as maternal risk factors for Down syndrome in Jordan.Semantic proximity Read ↗

Meta-analysis of Methylenetetrahydrofolate reductase maternal gene in Down syndrome: increased susceptibility in women carriers of the MTHFR 677T allele.Semantic proximity Read ↗

Betaine-homocysteine methyltransferase 742G>A polymorphism and risk of down syndrome offspring in a Brazilian population.Semantic proximity Read ↗

Down's Syndrome and Triple Negative Breast Cancer: A Rare Occurrence of Distinctive Clinical Relationship.Semantic proximity Read ↗

BHMT G742A and MTHFD1 G1958A polymorphisms and Down syndrome risk in the Brazilian population.Semantic proximity Read ↗

Association between FTO gene polymorphism and obesity in down syndrome children.Semantic proximity Read ↗

Maternal methylenetetrahydrofolate reductase C677T polymorphism and down syndrome risk: a meta-analysis from 34 studies.Semantic proximity Read ↗

Association of methylenetetrahydrofolate reductase gene 677C > T polymorphism and Down syndrome.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.