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Article

Association of methylenetetrahydrofolate reductase gene 677C > T polymorphism and Down syndrome.

Molecular biology reports - 1 Mar 2013

Costa-Lima Marcelo Aguiar, Amorim Márcia Rodrigues, Orioli Iêda Maria

Abstract excerpt

The association between Down syndrome (DS) and maternal polymorphisms in genes encoding folic acid metabolizing enzymes remains a controversial issue. A meta-analysis was performed to evaluate the association of maternal MTHFR 677C > T polymorphism and the risk of having a child with DS. Case-control studies were screened from major literature databases. Twenty articles from 13 countries worldwide, with a total...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 23184006
DOI: 10.1007/s11033-012-2270-z

Genes

MTHFR

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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