Article
Potential contribution of SIM2 and ETS2 functional polymorphisms in Down syndrome associated malignancies.
BMC medical genetics - 23 Jan 2013
Chatterjee Arpita, Dutta Samikshan, Mukherjee Sanjit, Mukherjee Nupur, Dutta Avirup, Mukherjee Ashis, Sinha Swagata, Panda Chinmay Kumar, Chaudhuri Keya, Roy Ananda L, Mukhopadhyay Kanchan
Abstract excerpt
BACKGROUND: Proper expression and functioning of transcription factors (TFs) are essential for regulation of different traits and thus could be crucial for the development of complex diseases. Subjects with Down syndrome (DS) have a higher incidence of acute lymphoblastic leukemia (ALL) while solid tumors, like breast cancer (BC) and oral cancer (OC), show rare incidences. Triplication of the human chromosome 21...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.