Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Meta-Analysis of DNA Methylation Datasets Shows Aberrant DNA Methylation of Thyroid Development or Function Genes in Down Syndrome.

Thyroid : official journal of the American Thyroid Association - 1 Jan 2023

Lauffer Peter, Zwaveling-Soonawala Nitash, Li Shaobo, Bacalini Maria G, Naumova Oxana Y, Wiemels Joseph, Boelen Anita, Henneman Peter, de Smith Adam J, van Trotsenburg A S Paul

Abstract excerpt

Background: In Down syndrome (DS), there is high occurrence of congenital hypothyroidism (CH) and subclinical hypothyroidism (SH) early in life. The etiology of CH and early SH in DS remains unclear. Previous research has shown genome-wide transcriptional and epigenetic alterations in DS. Thus, we hypothesized that CH and early SH could be caused by epigenetically driven transcriptional downregulation of...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Down Syndrome
Share to DNA Methylation

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Epigenesis, Genetic

Share to Phenotype

Share to Thyroid Gland

Source

Identifiers

PMID: 36326208
DOI: 10.1089/thy.2022.0320

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Meta-Analysis of DNA Methylation Datasets Shows Aberrant DNA Methylation of Thyroid Development or Function Genes in Down Syndrome.PMID 36326208Read ↗

Identification of a DNA methylation signature in blood cells from persons with Down SyndromeSemantic proximity Read ↗

DNA Methylation Alterations in Blood Cells of Toddlers with Down SyndromeSemantic proximity Read ↗

Low-Pass Whole Genome Bisulfite Sequencing of Neonatal Dried Blood Spots Identifies a Role for RUNX1 in Down Syndrome DNA Methylation ProfilesSemantic proximity Read ↗

Low-pass whole genome bisulfite sequencing of neonatal dried blood spots identifies a role for RUNX1 in Down syndrome DNA methylation profilesSemantic proximity Read ↗

Trans effects of chromosome aneuploidies on DNA methylation patterns in human Down syndrome and mouse modelsSemantic proximity Read ↗

The genome-wide impact of trisomy 21 on DNA methylation and its implications for hematopoiesisSemantic proximity Read ↗

Widespread domain-like perturbations of DNA methylation in whole blood of Down syndrome neonatesSemantic proximity Read ↗

Global DNA Hypermethylation in Down Syndrome PlacentaSemantic proximity Read ↗

Epigenomic signature of major congenital heart defects in newborns with Down syndromeSemantic proximity Read ↗

Epigenomic signature of major congenital heart defects in newborns with Down syndromeSemantic proximity Read ↗

Whole genome bisulfite sequencing of Down syndrome brain reveals regional DNA hypermethylation and novel disorder insightsSemantic proximity Read ↗

Epigenetic dysregulation in the developing Down syndrome cortexSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.