Article

MTHFR gene polymorphism and associated nutritional deficiency in the etiology and pathogenesis of Down syndrome

2019-09-04

Abstract excerpt

Our aim was to evaluate the influence of methylenetetrahydrofolate reductase (MTHFR) gene polymorphism on maternal risk for Down syndrome (DS) and observe the impact of this polymorphism on folate, homocysteine, and vitamin B 12 concentrations and their association with pregnancy outcome in addition to malformations in DS offspring. The prevalence of MTHFR gene polymorphism at 677 positions in mothers of DS childr...

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Literature Corpus work: 5a7560bb-96a3-5588-9a04-83f399bedab8
DOI: 10.1186/s43042-019-0010-9

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