Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Down's Syndrome and Triple Negative Breast Cancer: A Rare Occurrence of Distinctive Clinical Relationship.

International journal of molecular sciences - 7 Jun 2017

Dey Nandini, Krie Amy, Klein Jessica, Williams Kirstin, McMillan Amanda, Elsey Rachel, Sun Yuliang, Williams Casey, De Pradip, Leyland-Jones Brian

Abstract excerpt

Down's syndrome (DS), the most common genetic cause of significant intellectual disability in children and adults is caused by the trisomy of either all or a part of human chromosome 21 (HSA21). Patients with DS mostly suffer from characteristic tumor types. Although individual patients of DS are at a higher risk for acute leukemia and testicular cancers, other types of solid tumors including breast cancers are...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Antineoplastic Combined Chemotherapy Protocols
Share to Chromosomes, Human, Pair 21

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Comparative Genomic Hybridization

Share to Down Syndrome

Share to Immunohistochemistry

Share to Positron Emission Tomography Computed Tomography

Share to Triple Negative Breast Neoplasms

Share to Trisomy

Source

Open in PubMed Open full text

Identifiers

PMID: 28590426
DOI: 10.3390/ijms18061218
PMCID: PMC5486041

Genes

ERG
RUNX1
ASXL1
BRCA1
DDR2
NTRK1
SOX2

Variants

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Down's Syndrome and Triple Negative Breast Cancer: A Rare Occurrence of Distinctive Clinical Relationship.PMID 28590426Read ↗

Cowden syndrome: recognizing and managing a not-so-rare hereditary cancer syndrome.Semantic proximity Read ↗

A tumor profile in Down syndromeSemantic proximity Read ↗

A genomic approach to study down syndrome and cancer inverse comorbidity: untangling the chromosome 21Semantic proximity Read ↗

Ten Reasons Why People With Down Syndrome are Protected From the Development of Most Solid Tumors -A ReviewSemantic proximity Read ↗

Association between acquired uniparental disomy and homozygous mutations and HER2/ER/PR status in breast cancer.Semantic proximity Read ↗

Potential contribution of SIM2 and ETS2 functional polymorphisms in Down syndrome associated malignancies.Semantic proximity Read ↗

Cowden Syndrome: A Critical Review of the Clinical LiteratureSemantic proximity Read ↗

Genotype-Phenotype Correlations in Breast Cancer.Semantic proximity Read ↗

Opposite chromosome constitutions due to a familial translocation t(1;21)(q43;q22) in 2 cousins with development delay and congenital anomalies: A case report.Semantic proximity Read ↗

Pattern of malignant disorders in individuals with Down's syndrome.Semantic proximity Read ↗

Partial trisomy 21 with or without highly restricted Down syndrome critical region (HR-DSCR): report of two new cases and reanalysis of the genotype-phenotype association.Semantic proximity Read ↗

[Occurrence of cancer in individuals with Down syndrome].Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.