Article
Glucocorticoid-induced leucine zipper enhanced expression in dendritic cells is sufficient to drive regulatory T cells expansion in vivo.
Journal of immunology (Baltimore, Md. : 1950) - 15 Dec 2014
Calmette Joseph, Ellouze Mehdi, Tran Thi, Karaki Soumaya, Ronin Emilie, Capel Francis, Pallardy Marc, Bachelerie Françoise, Krzysiek Roman, Emilie Dominique, Schlecht-Louf Géraldine, Godot Véronique
Abstract excerpt
Tolerance induction by dendritic cells (DCs) is, in part, mediated by the activation of regulatory T cells (Tregs). We have previously shown in vitro that human DCs treated with glucocorticoids (GCs), IL-10, or TGF-β upregulate the GC-Induced Leucine Zipper protein (GILZ). GILZ overexpression pro...
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