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Article

GILZ mediates the antiproliferative activity of glucocorticoids by negative regulation of Ras signaling.

The Journal of clinical investigation - 1 Jun 2007

Ayroldi Emira, Zollo Ornella, Bastianelli Alessandra, Marchetti Cristina, Agostini Massimiliano, Di Virgilio Rosa, Riccardi Carlo

Abstract excerpt

Tsc22d3 coding for glucocorticoid-induced leucine zipper (GILZ) was initially identified as a dexamethasone-responsive gene involved in the control of T lymphocyte activation and apoptosis. However, the physiological role of this molecule and its function in the biological activity of glucocorticoids (GCs) has not been clarified. Here, we demonstrate that GILZ interacts directly with Ras in vitro and in vivo as...

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Identifiers

PMID: 17492054
DOI: 10.1172/JCI30724
PMCID: PMC1865030

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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