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Article

Increased GILZ expression in transgenic mice up-regulates Th-2 lymphokines

5 Oct 2005

Abstract excerpt

GILZ (glucocorticoid-induced leucine zipper), a gene induced by dexamethasone, is involved in control of T lymphocyte activation and apoptosis. In the present study, using Gilz transgenic mice (TG), which overexpress GILZ in the T-cell lineage, we demonstrate that Gilz is implicated in T helper-2 (Th-2) response development. After in vitro stimulation by CD3/CD28 antibodies, peripheral naive CD4+ T cells from TG...

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Identifiers

PMID: 16204313
DOI: 10.1182/blood-2005-05-2183

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