Development of novel treatment strategies for inflammatory diseases—similarities and divergence between glucocorticoids and GILZ

Abstract excerpt

Glucocorticoids (GC) are the most commonly prescribed medications for patients with inflammatory diseases, despite their well-known adverse metabolic effects. Previously, it was understood that the anti-inflammatory effects of the GC/GC receptor (GR) complex were mediated via transrepression, whilst the adverse metabolic effects were mediated via transactivation. It has recently become clear that this "divergent...

Topics

Share this publication in a Topic to start or enrich a Post.

• Share to Adrenal Hormones and Disorders
• Share to Cytokine Signaling Pathways and Interactions
• Share to Immune Response and Inflammation