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Article

Proinflammatory Th17 cells are expanded and induced by dendritic cells in spondylarthritis-prone HLA-B27-transgenic rats.

Arthritis and rheumatism - 1 Jan 2012

Glatigny Simon, Fert Ingrid, Blaton Marie A, Lories Rik J, Araujo Luiza M, Chiocchia Gilles, Breban Maxime

Abstract excerpt

OBJECTIVE: HLA-B27/human β2-microglobulin-transgenic (B27-transgenic) rats, a model of spondylarthritis (SpA), develop spontaneous colitis and arthritis under conventional conditions. CD4+ T cells are pivotal in the development of inflammation in B27-transgenic rats. This study was undertaken to characterize the phenotype of CD4+ T cells in this model and to determine whether dendritic cells (DCs) induce...

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Identifiers

PMID: 21905004
DOI: 10.1002/art.33321

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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