Article
Identification of seven genes essential for male fertility through a genome-wide association study of non-obstructive azoospermia and RNA interference-mediated large-scale functional screening in Drosophila.
Human molecular genetics - 1 Mar 2015
Yu Jun, Wu Hao, Wen Yang, Liu Yujuan, Zhou Tao, Ni Bixian, Lin Yuan, Dong Jing, Zhou Zuomin, Hu Zhibin, Guo Xuejiang, Sha Jiahao, Tong Chao
Abstract excerpt
Non-obstructive azoospermia (NOA) is a complex and severe condition whose etiology remains largely unknown. In a genome-wide association study (GWAS) of NOA in Chinese men, few loci reached genome-wide significance, although this might be a result of genetic heterogeneity. Single nucleotide polymorphisms (SNPs) without genome-wide significance may also indicate genes that are essential for fertility, and multiple...
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