CHES-1-like, the ortholog of a non-obstructive azoospermia-associated gene, blocks germline stem cell differentiation by upregulating Dpp expression in Drosophila testis.

doi:10.18632/oncotarget.9789

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Article

CHES-1-like, the ortholog of a non-obstructive azoospermia-associated gene, blocks germline stem cell differentiation by upregulating Dpp expression in Drosophila testis.

Oncotarget - 5 Jul 2016

Yu Jun, Liu Yujuan, Lan Xiang, Wu Hao, Wen Yang, Zhou Zuomin, Hu Zhibin, Sha Jiahao, Guo Xuejiang, Tong Chao

Abstract excerpt

Azoospermia is a high risk factor for testicular germ cell tumors, whose underlying molecular mechanisms remain unknown. In a genome-wide association study to identify novel loci associated with human non-obstructive azoospermia (NOA), we uncovered a single nucleotide polymorphism (rs1887102, P=2.60 ×10-7) in a human gene FOXN3. FOXN3 is an evolutionarily conserved gene. We used Drosophila melanogaster as a model...

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PMID: 27281616
DOI: 10.18632/oncotarget.9789
PMCID: PMC5173136

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FOXN3

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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