Article
Pathogenic variants screening in five non-obstructive azoospermia-associated genes.
Molecular human reproduction - 1 Feb 2014
Lu Chuncheng, Xu Miaofei, Wang Rong, Qin Yufeng, Wang Ying, Wu Wei, Song Ling, Wang Shoulin, Shen Hongbing, Sha Jiahao, Miao Dengshun, Hu Zhibin, Xia Yankai, Wang Xinru
Abstract excerpt
Non-obstructive azoospermia (NOA) is one of the most severe forms of male infertility and a recent, genome-wide association study (GWAS) has identified four risk loci associated with NOA. However, a large portion of the heritability of NOA has not been well explained by GWAS. By hypothesizing that rare, low-frequency and common genetic variants might point toward a causal relation between candidate genes and NOA,...
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