Article
Association analysis identifies new risk loci for non-obstructive azoospermia in Chinese men.
Nature communications - 23 May 2014
Hu Zhibin, Li Zheng, Yu Jun, Tong Chao, Lin Yuan, Guo Xuejiang, Lu Feng, Dong Jing, Xia Yankai, Wen Yang, Wu Hao, Li Honggang, Zhu Yong, Ping Ping, Chen Xiangfeng, Dai Juncheng, Jiang Yue, Pan Shandong, Xu Peng, Luo Kailing, Du Qiang, Yao Bing, Liang Ming, Gui Yaoting, Weng Ning, Lu Hui, Wang Zhuqing, Zhang Fengbin, Zhu Xiaobin, Yang Xiaoyu, Zhang Zhou, Zhao Han, Xiong Chenliang, Ma Hongxia, Jin Guangfu, Chen Feng, Xu Jianfeng, Wang Xinru, Zhou Zuomin, Chen Zi-Jiang, Liu Jiayin, Shen Hongbing, Sha Jiahao
Abstract excerpt
Male factor infertility affects one-sixth of couples worldwide, and non-obstructive azoospermia (NOA) is one of the most severe forms. Our previous genome-wide association study (GWAS) identified three susceptibility loci for NOA in Han Chinese men. Here we test promising associations in an extended three-stage validation using 3,608 NOA cases and 5,909 controls to identify additional risk loci. We find strong...
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