Article
Higher metastatic efficiency of KRas G12V than KRas G13D in a colorectal cancer model.
FASEB journal : official publication of the Federation of American Societies for Experimental Biology - 1 Feb 2015
Alamo Patricia, Gallardo Alberto, Di Nicolantonio Federica, Pavón Miguel Angel, Casanova Isolda, Trias Manuel, Mangues María Antonia, Lopez-Pousa Antonio, Villaverde Antonio, Vázquez Esther, Bardelli Alberto, Céspedes María Virtudes, Mangues Ramón
Abstract excerpt
Although all KRas (protein that in humans is encoded by the KRas gene) point mutants are considered to have a similar prognostic capacity, their transformation and tumorigenic capacities vary widely. We compared the metastatic efficiency of KRas G12V (Kirsten rat sarcoma viral oncogene homolog with valine mutation at codon 12) and KRas G13D (Kirsten rat sarcoma viral oncogene homolog with aspartic mutation at...
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