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Article

The impact of KRAS mutations on VEGF-A production and tumour vascular network.

BMC cancer - 18 Mar 2013

Figueras Agnès, Arbos Maria Antonia, Quiles Maria Teresa, Viñals Francesc, Germà Josep Ramón, Capellà Gabriel

Abstract excerpt

BACKGROUND: The malignant potential of tumour cells may be influenced by the molecular nature of KRAS mutations being codon 13 mutations less aggressive than codon 12 ones. Their metabolic profile is also different, with an increased anaerobic glycolytic metabolism in cells harbouring codon 12 KRAS mutations compared with cells containing codon 13 mutations. We hypothesized that this distinct metabolic behaviour...

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Source

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Identifiers

PMID: 23506169
DOI: 10.1186/1471-2407-13-125
PMCID: PMC3610256

Genes

KRAS
MVD

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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