Article
Phenotype of asthmatics with increased airway S-nitrosoglutathione reductase activity.
The European respiratory journal - 1 Jan 2015
Marozkina Nadzeya V, Wang Xin-Qun, Stsiapura Vitali, Fitzpatrick Anne, Carraro Silvia, Hawkins Gregory A, Bleecker Eugene, Meyers Deborah, Jarjour Nizar, Fain Sean B, Wenzel Sally, Busse William, Castro Mario, Panettieri Reynold A, Moore Wendy, Lewis Stephen J, Palmer Lisa A, Altes Talissa, de Lange Eduard E, Erzurum Serpil, Teague W Gerald, Gaston Benjamin
Abstract excerpt
S-Nitrosoglutathione is an endogenous airway smooth muscle relaxant. Increased airway S-nitrosoglutathione breakdown occurs in some asthma patients. We asked whether patients with increased airway catabolism of this molecule had clinical features that distinguished them from other asthma patients. We measured S-nitrosoglutathione reductase expression and activity in bronchoscopy samples taken from 66 subjects in...
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