Article
Use of exhaled nitric oxide measurement to identify a reactive, at-risk phenotype among patients with asthma.
American journal of respiratory and critical care medicine - 15 May 2010
Dweik Raed A, Sorkness Ronald L, Wenzel Sally, Hammel Jeffrey, Curran-Everett Douglas, Comhair Suzy A A, Bleecker Eugene, Busse William, Calhoun William J, Castro Mario, Chung Kian Fan, Israel Elliot, Jarjour Nizar, Moore Wendy, Peters Stephen, Teague Gerald, Gaston Benjamin, Erzurum Serpil C
Abstract excerpt
RATIONALE: Exhaled nitric oxide (Fe(NO)) is a biomarker of airway inflammation in mild to moderate asthma. However, whether Fe(NO) levels are informative regarding airway inflammation in patients with severe asthma, who are refractory to conventional treatment, is unknown. Here, we hypothesized that classification of severe asthma based on airway inflammation as defined by Fe(NO) levels would identify a more...
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