Article
Airway inflammation assessed by invasive and noninvasive means in severe asthma: eosinophilic and noneosinophilic phenotypes.
The Journal of allergy and clinical immunology - 1 Nov 2006
Lemière Catherine, Ernst Pierre, Olivenstein Ron, Yamauchi Yasuhiro, Govindaraju Karuthapillai, Ludwig Mara S, Martin James G, Hamid Qutayba
Abstract excerpt
BACKGROUND: Airway inflammation assessed by bronchial biopsies demonstrates distinct eosinophilic and noneosinophilic phenotypes in severe asthma, but their relationship to other biomarkers of disease (induced sputum and nitric oxide [NO]) is not clear. OBJECTIVES: We sought to compare airway inflammation using noninvasive (induced sputum, exhaled NO), and invasive (bronchial biopsies) methods in moderate and...
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