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Article

Peptide selectivity discriminates NK cells from KIR2DL2- and KIR2DL3-positive individuals.

European journal of immunology - 1 Feb 2015

Cassidy Sorcha, Mukherjee Sayak, Myint Thet Mon, Mbiribindi Berenice, North Helen, Traherne James, Mulder Arend, Claas Frans H J, Purbhoo Marco A, Das Jayajit, Khakoo Salim I

Abstract excerpt

Natural killer cells are controlled by peptide selective inhibitory receptors for MHC class I, including the killer cell immunoglobulin-like receptors (KIRs). Despite having similar ligands, KIR2DL2 and KIR2DL3 confer different levels of protection to infectious disease. To investigate how changes in peptide repertoire may differentially affect NK cell reactivity, NK cells from KIR2DL2 and KIR2DL3 homozygous...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 25359276
DOI: 10.1002/eji.201444613
PMCID: PMC4324016

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

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Peptide selectivity discriminates NK cells from KIR2DL2- and KIR2DL3-positive individuals.PMID 25359276Read ↗

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Mutation at positively selected positions in the binding site for HLA-C shows that KIR2DL1 is a more refined but less adaptable NK cell receptor than KIR2DL3.Semantic proximity Read ↗

Mutational and structural analysis of KIR3DL1 reveals a lineage-defining allotypic dimorphism that impacts both HLA and peptide sensitivity.Semantic proximity Read ↗

Variable NK cell receptors exemplified by human KIR3DL1/S1.Semantic proximity Read ↗

Peptide-specific engagement of the activating NK cell receptor KIR2DS1.Semantic proximity Read ↗

Large spectrum of HLA-C recognition by killer Ig-like receptor (KIR)2DL2 and KIR2DL3 and restricted C1 SPECIFICITY of KIR2DS2: dominant impact of KIR2DL2/KIR2DS2 on KIR2D NK cell repertoire formation.Semantic proximity Read ↗

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Discrimination between the main activating and inhibitory killer cell immunoglobulin-like receptor positive natural killer cell subsets using newly characterized monoclonal antibodies.Semantic proximity Read ↗

Synergistic polymorphism at two positions distal to the ligand-binding site makes KIR2DL2 a stronger receptor for HLA-C than KIR2DL3.Semantic proximity Read ↗

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