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Article

Identification of a class of HCV inhibitors directed against the nonstructural protein NS4B.

Science translational medicine - 20 Jan 2010

Cho Nam-Joon, Dvory-Sobol Hadas, Lee Choongho, Cho Sang-Joon, Bryson Paul, Masek Marilyn, Elazar Menashe, Frank Curtis W, Glenn Jeffrey S

Abstract excerpt

New classes of drugs are needed to combat hepatitis C virus (HCV), an important worldwide cause of liver disease. We describe an activity of a key domain, an amphipathic helix we termed 4BAH2, within a specific HCV nonstructural protein, NS4B. In addition to its proposed role in viral replication, we validate 4BAH2 as essential for HCV genome replication and identify first-generation small-molecule inhibitors of...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 20371471
DOI: 10.1126/scitranslmed.3000331
PMCID: PMC3025298

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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