Article
Copper-mediated neurotoxicity and genetic vulnerability in the background of neurodegenerative diseases in C. elegans.
Toxicological sciences : an official journal of the Society of Toxicology - 1 Oct 2024
Weishaupt Ann-Kathrin, Ruecker Lysann, Meiners Torben, Schwerdtle Tanja, Silva Avila Daiana, Aschner Michael, Bornhorst Julia
Abstract excerpt
The mechanisms associated with neurodegenerative diseases, such as Alzheimer's disease (AD) and Parkinson's disease (PD), have yet to be fully characterized, and genetic as well as environmental factors in their disease etiology are underappreciated. Although mutations in genes such as PARKIN and LRRK2 have been linked to PD, the idiopathic component of the disease suggests a contribution of environmental risk...
Topics
- Caenorhabditis elegans
- Animals
- Copper
- Caenorhabditis elegans Proteins
- Parkinson Disease
- Neurodegenerative Diseases
- Ubiquitin-Protein Ligases
- Alzheimer Disease
- Leucine-Rich Repeat Serine-Threonine Protein Kinase-2
- Mutation
- Animals, Genetically Modified
- Genetic Predisposition to Disease