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DICER1/ <i>Alu</i> RNA dysmetabolism induces Caspase-8–mediated cell death in age-related macular degeneration

27 Oct 2014

Abstract excerpt

Geographic atrophy, an advanced form of age-related macular degeneration (AMD) characterized by death of the retinal pigmented epithelium (RPE), causes untreatable blindness in millions worldwide. The RPE of human eyes with geographic atrophy accumulates toxic Alu RNA in response to a deficit in the enzyme DICER1, which in turn leads to activation of the NLRP3 inflammasome and elaboration of IL-18. Despite these...

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PMID: 25349431
DOI: 10.1073/pnas.1403814111

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