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Article

TLR-Independent and P2X7-Dependent Signaling Mediate<i>Alu</i>RNA-Induced NLRP3 Inflammasome Activation in Geographic Atrophy

11 Oct 2013

Abstract excerpt

PURPOSE: Accumulation of Alu RNA transcripts due to DICER1 deficiency in the retinal pigmented epithelium (RPE) promotes geographic atrophy. Recently we showed that Alu RNA activated the NLRP3 inflammasome, leading to RPE cell death via interleukin-18 (IL-18)-mediated MyD88 signaling. However, the molecular basis for NLRP3 inflammasome activation by Alu RNA is not well understood. We sought to decipher the key...

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PMID: 24114535
DOI: 10.1167/iovs.13-12500

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