Article
DICER1 deficit induces Alu RNA toxicity in age-related macular degeneration.
Nature - 17 Mar 2011
Kaneko Hiroki, Dridi Sami, Tarallo Valeria, Gelfand Bradley D, Fowler Benjamin J, Cho Won Gil, Kleinman Mark E, Ponicsan Steven L, Hauswirth William W, Chiodo Vince A, Karikó Katalin, Yoo Jae Wook, Lee Dong-ki, Hadziahmetovic Majda, Song Ying, Misra Smita, Chaudhuri Gautam, Buaas Frank W, Braun Robert E, Hinton David R, Zhang Qing, Grossniklaus Hans E, Provis Jan M, Madigan Michele C, Milam Ann H, Justice Nikki L, Albuquerque Romulo J C, Blandford Alexander D, Bogdanovich Sasha, Hirano Yoshio, Witta Jassir, Fuchs Elaine, Littman Dan R, Ambati Balamurali K, Rudin Charles M, Chong Mark M W, Provost Patrick, Kugel Jennifer F, Goodrich James A, Dunaief Joshua L, Baffi Judit Z, Ambati Jayakrishna
Abstract excerpt
Geographic atrophy (GA), an untreatable advanced form of age-related macular degeneration, results from retinal pigmented epithelium (RPE) cell degeneration. Here we show that the microRNA (miRNA)-processing enzyme DICER1 is reduced in the RPE of humans with GA, and that conditional ablation of Dicer1, but not seven other miRNA-processing enzymes, induces RPE degeneration in mice. DICER1 knockdown induces...
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