The relationship between Mycobacterium tuberculosis MGIT time to positivity and cfu in sputum samples demonstrates changing bacterial phenotypes potentially reflecting the impact of chemotherapy on critical sub-populations.

doi:10.1093/jac/dku415

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Article

The relationship between Mycobacterium tuberculosis MGIT time to positivity and cfu in sputum samples demonstrates changing bacterial phenotypes potentially reflecting the impact of chemotherapy on critical sub-populations.

The Journal of antimicrobial chemotherapy - 1 Feb 2015

Bowness Ruth, Boeree Martin J, Aarnoutse Rob, Dawson Rodney, Diacon Andreas, Mangu Chacha, Heinrich Norbert, Ntinginya Nyanda E, Kohlenberg Anke, Mtafya Bariki, Phillips Patrick P J, Rachow Andrea, Plemper van Balen Georgette, Gillespie Stephen H

Abstract excerpt

OBJECTIVES: The relationship between cfu and Mycobacterial Growth Indicator Tube (MGIT) time to positivity (TTP) is uncertain. We attempted to understand this relationship and create a mathematical model to relate these two methods of determining mycobacterial load. METHODS: Sequential bacteriological load data from clinical trials determined by MGIT and cfu were collected and mathematical models derived. All...

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PMID: 25344806
DOI: 10.1093/jac/dku415

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

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