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Article

Serial image analysis of Mycobacterium tuberculosis colony growth reveals a persistent subpopulation in sputum during treatment of pulmonary TB.

Tuberculosis (Edinburgh, Scotland) - 1 May 2016

Barr David A, Kamdolozi Mercy, Nishihara Yo, Ndhlovu Victor, Khonga Margaret, Davies Geraint R, Sloan Derek J

Abstract excerpt

Faster elimination of drug tolerant 'persister' bacteria may shorten treatment of tuberculosis (TB) but no method exists to quantify persisters in clinical samples. We used automated image analysis to assess whether studying growth characteristics of individual Mycobacterium tuberculosis colonies from sputum on solid media during early TB treatment facilitates 'persister' phenotyping. As Time to Detection (TTD)...

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Identifiers

PMID: 27156626
DOI: 10.1016/j.tube.2016.03.001
PMCID: PMC4869592

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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