Article

Investigation into mycobacterial persistence and early markers of outcome in the treatment of pulmonary tuberculosis

2013-01-01

Abstract excerpt

Background: Development of ultra-short chemotherapy for tuberculosis (TB) is thwarted by drug-tolerant bacillary persistence and a lack of surrogate endpoints to predict outcome from early clinical studies. Characterising bacillary elimination amongst TB patients may provide important new information. Bacilli harbouring intra-cytoplasmic lipid bodies (LBs) may represent a drug-tolerant phenotype, responsible for d...

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Literature Corpus work: adeced2f-5b6a-5b98-83f7-9886c10ebab5
DOI: 10.17638/00012873

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