Article
Small interfering RNA against CD86 during allergen challenge blocks experimental allergic asthma.
Respiratory research - 27 Oct 2014
Asai-Tajiri Yukari, Matsumoto Koichiro, Fukuyama Satoru, Kan-O Keiko, Nakano Takako, Tonai Ken, Ohno Tatsukuni, Azuma Miyuki, Inoue Hiromasa, Nakanishi Yoichi
Abstract excerpt
BACKGROUND: CD86-CD28 interaction has been suggested as the principal costimulatory pathway for the activation and differentiation of naïve T cells in allergic inflammation. However, it remains uncertain whether this pathway also has an essential role in the effector phase. We sought to determine the contribution of CD86 on dendritic cells in the reactivation of allergen-specific Th2 cells. METHODS: We...
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