Article

Trained Immunity Induced by in Vivo Peptide-Based STAT6 Inhibition Prevents Ragweed Allergy in Mice

2020-12-09

Abstract excerpt

<title>Abstract</title> <p>BackgroundAllergic airways disease (AAD) is initiated, maintained by the type 2 (T2) inflammatory pathway, and is partially regulated by cytokines IL-4 and IL-13 following activation of the STAT6 transcription factor. ObjectiveTo investigate mucosal immune responses, using neonatal vaccination with the STAT6 inhibitory peptide (STAT6-IP), to prevent the development of ragweed-induced AA...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 753290f2-7095-54cb-8294-9e6263c21068
DOI: 10.21203/rs.3.rs-122121/v1

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Trained Immunity Induced by in Vivo Peptide-Based STAT6 Inhibition Prevents Ragweed Allergy in MiceDOI 10.21203/rs.3.rs-122121/v1Read

Immunization with an adeno-associated viral vectored allergy vaccine containing Der p1-Der p2 effectively alleviates an asthmatic phenotype in miceSemantic proximity Read

A combination TLR7/8 and RIG-I agonist adjuvant reverts asthmatic allergic sensitization and prevents aggravated influenza infection in OVA-sensitized miceSemantic proximity Read

Allergen‐Specific Immunotherapy and Trained ImmunitySemantic proximity Read

Regulation of Th2 Responses and Allergic Inflammation through Bystander Activation of CD8+ T Lymphocytes in Early LifeSemantic proximity Read

Immune Training of the Interleukin 6 Gene in Airway Epithelial Cells is Central to Asthma ExacerbationsSemantic proximity Read

NO2 inhalation induces maturation of pulmonary CD11c+ cells that promote antigenspecific CD4+ T cell polarization.Semantic proximity Read

Persistent activation of dendritic cells after resolution of allergic airway inflammation breaks tolerance to inhaled allergens in mice.Semantic proximity Read

A viral PAMP double‐stranded RNA induces allergen‐specific Th17 cell response in the airways which is dependent on VEGF and IL‐6Semantic proximity Read

Differences in phenotype, homing properties and suppressive activities of regulatory T cells induced by epicutaneous, oral or sublingual immunotherapy in mice sensitized to peanut.Semantic proximity Read

Transfer of in vivo primed transgenic T cells supports allergic lung inflammation and FIZZ1 and Ym1 production in an IL-4Rα and STAT6 dependent mannerSemantic proximity Read

β5i subunit deficiency of the immunoproteasome leads to reduced Th2 response in OVA induced acute asthma.Semantic proximity Read

Antigen-specific effector CD8 T cells regulate allergic responses via IFN-γ and dendritic cell function.Semantic proximity Read