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Article

TRAIL-mediated apoptosis in breast cancer cells cultured as 3D spheroids.

PloS one - 1 Jan 2014

Chandrasekaran Siddarth, Marshall Jocelyn R, Messing James A, Hsu Jong-Wei, King Michael R

Abstract excerpt

TNF-alpha-related-apoptosis-inducing-ligand (TRAIL) has been explored as a therapeutic drug to kill cancer cells. Cancer cells in the circulation are subjected to apoptosis-inducing factors. Despite the presence of these factors, cells are able to extravasate and metastasize. The homotypic and heterotypic cell-cell interactions in a tumor are known to play a crucial role in bestowing important characteristics to...

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Source

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Identifiers

PMID: 25343626
DOI: 10.1371/journal.pone.0111487
PMCID: PMC4208846

Genes

TNF

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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