Limited family structure and triple-negative breast cancer (TNBC) subtype as predictors of BRCA mutations in a genetic counseling cohort of early-onset sporadic breast cancers.

doi:10.1007/s10549-014-3167-4

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Limited family structure and triple-negative breast cancer (TNBC) subtype as predictors of BRCA mutations in a genetic counseling cohort of early-onset sporadic breast cancers.

Breast cancer research and treatment - 1 Nov 2014

Zugazagoitia Jon, Pérez-Segura Pedro, Manzano Arancha, Blanco Ignacio, Vega Ana, Custodio Ana, Teulé Alex, Fachal Laura, Martínez Beatriz, González-Sarmiento Rogelio, Cruz-Hernández Juan Jesús, Chirivella Isabel, Garcés Vicente, Garre Pilar, Romero Atocha, Caldés Trinidad, Díaz-Rubio Eduardo, de la Hoya Miguel

Abstract excerpt

Early-onset diagnosis is an eligibility criterion for BRCA1 and BRCA2 (BRCA) testing in sporadic breast cancer patients. Limited family structure has been proposed as a predictor of BRCA mutation status in this group of patients. An overwhelming amount of data supports a strong association between BRCA1 mutations and triple-negative breast cancer (TNBC). Here, we analyze the feasibility of using limited family...

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PMID: 25342642
DOI: 10.1007/s10549-014-3167-4

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BRCA1
BRCA2

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