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Article

Evaluation of the Dutch BRCA1/2 clinical genetic center referral criteria in an unselected early breast cancer population.

European journal of human genetics : EJHG - 1 May 2015

van den Broek Alexandra J, de Ruiter Karen, van 't Veer Laura J, Tollenaar Rob A E M, van Leeuwen Flora E, Verhoef Senno, Schmidt Marjanka K

Abstract excerpt

In this study, we evaluated the diagnostic value of the Dutch Clinical Genetic Center (CGC) referral guidelines for BRCA1/2 mutation testing in 903 early breast cancer patients, unselected for family history, diagnosed in a cancer hospital before the age of 50 years in 1974-2002; most prevalent Dutch pathogenic BRCA1/2 mutations had been analyzed on coded DNA in a research setting. Forty-nine (5.4%) of the...

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Source

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Identifiers

PMID: 25138101
DOI: 10.1038/ejhg.2014.161
PMCID: PMC4402636

Genes

BRCA1
BRCA2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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