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Article

CYLD mediates human pulmonary artery smooth muscle cell dysfunction in congenital heart disease-associated pulmonary arterial hypertension.

Journal of cellular physiology - 1 Sept 2021

Zhou Jing-Jing, Li Huang, Li Li, Li Yue, Wang Pei-He, Meng Xian-Min, He Jian-Guo

Abstract excerpt

Pulmonary arterial hypertension (PAH) is a common complication of congenital heart disease (CHD). Deubiquitinase cylindromatosis (CYLD) has been reported to significantly aggravate vascular smooth muscle cell (VSMC) phenotypic transformation, proliferation, and migration. Here, we aimed to further investigate its roles and underlying mechanisms in the CHD-PAH development. The expression of CYLD in the lung...

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Share to Deubiquitinating Enzyme CYLD
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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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PMID: 33507567
DOI: 10.1002/jcp.30298

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026.

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