Article
Clinical application of pharmacogenomics: the example of HLA-based drug-induced toxicity.
Public health genomics - 1 Jan 2014
Lee Ming Ta Michael, Mahasirimongkol Surakameth, Zhang Yanfei, Suwankesawong Wimon, Chaikledkaew Usa, Pavlidis Cristiana, Patrinos George P, Chantratita Wasun
Abstract excerpt
Pharmacogenomics is gradually becoming more and more indispensable in modern medicine. In several cases, a pharmacogenomics test may alleviate serious drug-induced adverse reactions, if it precedes drug prescription. In this article, we provide an overview of the well-established HLA-based carbamazepine- and allopurinol-induced adverse reactions, as one of the most characteristic examples of the clinical...
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