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Article

Comparison of neuroendocrine differentiation and KRAS/NRAS/BRAF/PIK3CA/TP53 mutation status in primary and metastatic colorectal cancer.

International journal of clinical and experimental pathology - 1 Jan 2014

Kleist Britta, Kempa Marcel, Novy Michael, Oberkanins Christian, Xu Li, Li Guojun, Loland Christiane, Poetsch Micaela

Abstract excerpt

Neuroendocrine differentiation of tumor tissue has been recognized as an important prerequisite for new targeted therapies. To evaluate the suitability of colorectal cancer (CRC) tissue for these treatment approaches and to find a possible link to pretherapeutic conditions of other targeted strategies, we compared neuroendocrine differentiation and KRAS/NRAS/BRAF/PIK3CA/TP53 mutational status in primary and...

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Biopsy
Class I Phosphatidylinositol 3-Kinases
GTP Phosphohydrolases
Lymphatic Metastasis
Neuroendocrine Tumors

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Phosphatidylinositol 3-Kinases

Proto-Oncogene Proteins p21(ras)

Source

Open in PubMed Open full text

Identifiers

PMID: 25337237
PMCID: PMC4203208

Genes

KRAS
BRAF
NRAS

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 1 Sept 2026.

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