Article
Synaptophysin expression in V600EBRAF-mutated advanced colorectal cancers identifies a new subgroup of tumours with worse prognosis.
European journal of cancer (Oxford, England : 1990) - 1 Mar 2021
Fassan Matteo, Milione Massimo, Maddalena Giulia, Cremolini Chiara, Schirripa Marta, Pietrantonio Filippo, Pella Nicoletta, Dell'Aquila Emanuela, Sperti Elisa, Zichi Clizia, Bergamo Francesca, Volante Marco, Boccaccino Alessandra, Morano Federica, Cortiula Francesco, De Maglio Giovanna, Rimassa Lorenza, Smiroldo Valeria, Calvetti Lorenzo, Aprile Giuseppe, Salvatore Lisa, Santini Daniele, Salmaso Roberta, Centonze Giovanni, Biason Paola, Borga Chiara, Lonardi Sara, Zagonel Vittorina, Dei Tos Angelo P, Di Maio Massimo, Loupakis Fotios
Abstract excerpt
BACKGROUND: Neuroendocrine differentiation has been extensively associated with worse prognosis and to mechanisms of therapy resistance in several epithelial cancers. A high prevalence of neuroendocrine differentiation was recently described in V600EBRAF-mutated (BRAFmt) metastatic colorectal cancers (mCRCs) but no data are available about its prognostic impact in this setting. METHODS: We assessed synaptophysin...
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