Article
A CRISPR view of development.
Genes & development - 1 Sept 2014
Harrison Melissa M, Jenkins Brian V, O'Connor-Giles Kate M, Wildonger Jill
Abstract excerpt
The CRISPR (clustered regularly interspaced short palindromic repeat)-Cas9 (CRISPR-associated nuclease 9) system is poised to transform developmental biology by providing a simple, efficient method to precisely manipulate the genome of virtually any developing organism. This RNA-guided nuclease (RGN)-based approach already has been effectively used to induce targeted mutations in multiple genes simultaneously,...
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