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Article

An RGD motif present in cadherin 17 induces integrin activation and tumor growth.

The Journal of biological chemistry - 12 Dec 2014

Bartolomé Rubén A, Peláez-García Alberto, Gomez Inmaculada, Torres Sofía, Fernandez-Aceñero María Jesús, Escudero-Paniagua Beatriz, Imbaud J Ignacio, Casal J Ignacio

Abstract excerpt

Little is known about the mechanism of integrin activation by cadherin 17 (CDH17). Here we observed the presence of a tri-peptide motif, RGD, in domain 6 of the human CDH17 sequence and other cadherins such as cadherin 5 and cadherin 6. The use of CDH17 RAD mutants demonstrated a considerable decrease of proliferation and adhesion in RKO and KM12SM colon cancer cells. Furthermore, RGD peptides inhibited the...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 25336636
DOI: 10.1074/jbc.M114.600502
PMCID: PMC4263880

Genes

CDH17

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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