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Article

Targeting Beta-3 integrin using a linear hexapeptide labeled with a near-infrared fluorescent molecular probe.

Molecular pharmaceutics - 1 Jan 2000

Bloch Sharon, Xu Baogang, Ye Yunpeng, Liang Kexian, Nikiforovich Gregory V, Achilefu Samuel

Abstract excerpt

Biomolecules containing the RGD peptide sequence are known to bind integrins with high affinity. Studies of hexa-and hepta-peptides labeled with a near-infrared fluorescent probe (cypate) showed that rearranging the glycine in a linear RGD peptide sequence to form the GRD analogue favored the uptake of the GRD compound by alphavbeta3 integrin receptor (ABIR)-positive A549 tumor cells and tissue. The...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 17009853
DOI: 10.1021/mp0600642

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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