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Article

Expression, purification, and characterization of RGD-mda-7, a His-tagged mda-7/IL-24 mutant protein.

Journal of immunoassay & immunochemistry - 1 Jan 2012

Liu Jun-Jie, Zhang Bao-Fu, Yin Xiao-Xing, Pei Dong-Sheng, Yang Zhi-Xia, Di Jie-Hui, Chen Fei-Fei, Li Hui-Zhong, Xu Wei, Wu Yong-Ping, Zheng Jun-Nian

Abstract excerpt

RGD peptide (Arg-Gly-Asp tripeptide) binds to integrin αVβ(3) and αVβ(5), which is selectively expressed in tumor neovasculature and on the surface of some tumor cells. Some studies showed that coupling the RGD peptides to anticancer drugs yielded compounds with increased efficiency against tumors and lowered toxicity to normal tissues. The melanoma differentiation-associated gene-7/interleukin-24 gene...

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Identifiers

PMID: 22963485
DOI: 10.1080/15321819.2012.659782

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