Article
Potential non-B DNA regions in the human genome are associated with higher rates of nucleotide mutation and expression variation.
Nucleic acids research - 10 Nov 2014
Du Xiangjun, Gertz E Michael, Wojtowicz Damian, Zhabinskaya Dina, Levens David, Benham Craig J, Schäffer Alejandro A, Przytycka Teresa M
Abstract excerpt
While individual non-B DNA structures have been shown to impact gene expression, their broad regulatory role remains elusive. We utilized genomic variants and expression quantitative trait loci (eQTL) data to analyze genome-wide variation propensities of potential non-B DNA regions and their relation to gene expression. Independent of genomic location, these regions were enriched in nucleotide variants. Our...
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