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Article

Wnt-5/pipetail functions in vertebrate axis formation as a negative regulator of Wnt/beta-catenin activity.

The Journal of cell biology - 1 Sept 2003

Westfall Trudi A, Brimeyer Ryan, Twedt Jen, Gladon Jean, Olberding Andrea, Furutani-Seiki Makoto, Slusarski Diane C

Abstract excerpt

We provide genetic evidence defining a role for noncanonical Wnt function in vertebrate axis formation. In zebrafish, misexpression of Wnt-4, -5, and -11 stimulates calcium (Ca2+) release, defining the Wnt/Ca2+ class. We describe genetic interaction between two Wnt/Ca2+ members, Wnt-5 (pipetail) and Wnt-11 (silberblick), and a reduction of Ca2+ release in Wnt-5/pipetail. Embryos genetically depleted of both...

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Identifiers

PMID: 12952939
DOI: 10.1083/jcb.200303107
PMCID: PMC2172822

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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