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Article

An in silico agent-based model demonstrates Reelin function in directing lamination of neurons during cortical development.

PloS one - 1 Jan 2014

Caffrey James R, Hughes Barry D, Britto Joanne M, Landman Kerry A

Abstract excerpt

The characteristic six-layered appearance of the neocortex arises from the correct positioning of pyramidal neurons during development and alterations in this process can cause intellectual disabilities and developmental delay. Malformations in cortical development arise when neurons either fail to migrate properly from the germinal zones or fail to cease migration in the correct laminar position within the...

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Source

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Identifiers

PMID: 25334023
DOI: 10.1371/journal.pone.0110415
PMCID: PMC4204858

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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