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Article

Selected ABCB1, ABCB4 and ABCC2 polymorphisms do not enhance the risk of drug-induced hepatotoxicity in a Spanish cohort.

PloS one - 1 Jan 2014

Ulzurrun Eugenia, Stephens Camilla, Ruiz-Cabello Francisco, Robles-Diaz Mercedes, Saenz-López Pablo, Hallal Hacibe, Soriano German, Roman Eva, Fernandez M Carmen, Lucena M Isabel, Andrade Raúl J

Abstract excerpt

BACKGROUND AND AIMS: Flawed ABC transporter functions may contribute to increased risk of drug-induced liver injury (DILI). We aimed to analyse the influence of genetic variations in ABC transporters on the risk of DILI development and clinical presentations in a large Spanish DILI cohort. METHODS: A total of ten polymorphisms in ABCB1 (1236T>C, 2677G>T,A, 3435T>C), ABCB4 (1954A>G) and ABCC2 (-1774G>del,...

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Share to ATP Binding Cassette Transporter, Subfamily B
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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 24732756
DOI: 10.1371/journal.pone.0094675
PMCID: PMC3986086

Genes

ABCC2
ABCB1
ABCB4

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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