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Article

Substrate trapping proteomics reveals targets of the βTrCP2/FBXW11 ubiquitin ligase.

Molecular and cellular biology - 1 Jan 2015

Kim Tai Young, Siesser Priscila F, Rossman Kent L, Goldfarb Dennis, Mackinnon Kathryn, Yan Feng, Yi XianHua, MacCoss Michael J, Moon Randall T, Der Channing J, Major Michael B

Abstract excerpt

Defining the full complement of substrates for each ubiquitin ligase remains an important challenge. Improvements in mass spectrometry instrumentation and computation and in protein biochemistry methods have resulted in several new methods for ubiquitin ligase substrate identification. Here we used the parallel adapter capture (PAC) proteomics approach to study βTrCP2/FBXW11, a substrate adaptor for the...

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Identifiers

PMID: 25332235
DOI: 10.1128/MCB.00857-14
PMCID: PMC4295375

Genes

RAPGEF2
CUL1
SKP1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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