The Fbw7 and betaTRCP E3 ubiquitin ligases and their roles in tumorigenesis.

Abstract excerpt

The Ubiquitin Proteasome System (UPS) is a major regulator of protein abundance in the cell. The UPS influences the functions of multiple biological processes by targeting key regulators for destruction. E3 ubiquitin ligases are a vital component of the UPS machinery, working with E1 and E2 enzymes to bind substrates and facilitate the transfer of ubiquitin molecules onto the target protein. This...

Topics

Share this publication in a Topic to start or enrich a Post.

• Share to F-Box Proteins
• Share to F-Box-WD Repeat-Containing Protein 7
• Share to Genes, Tumor Suppressor