Article
The putative signal peptide of glucagon-like peptide-1 receptor is not required for receptor synthesis but promotes receptor expression.
Bioscience reports - 21 Nov 2014
Ge Yunjun, Yang Dehua, Dai Antao, Zhou Caihong, Zhu Yue, Wang Ming-Wei
Abstract excerpt
GLP-1R (glucagon-like peptide-1 receptor) mediates the 'incretin effect' and many other anti-diabetic actions of its cognate ligand, GLP-1 (glucagon-like peptide-1). It belongs to the class B family of GPCRs (G protein-coupled receptors) and possesses an N-terminal putative SP (signal peptide). I...
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