Association of the C3953T (rs1143634) variant of the interleukin 1 beta gene with the features of a complicated course of COVID-19-associated pneumonia.

doi:10.1007/s11033-024-09569-4

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Association of the C3953T (rs1143634) variant of the interleukin 1 beta gene with the features of a complicated course of COVID-19-associated pneumonia.

Molecular biology reports - 8 May 2024

Pokhylko Valeriy, Cherniavska Yuliia, Fishchuk Liliia, Rossokha Zoia, Popova Olena, Vershyhora Viktoriia, Ievseienkova Olena, Soloviova Halyna, Zhuk Liudmyla, Gorovenko Nataliia

Abstract excerpt

BACKGROUND: The pro-inflammatory cytokine IL-1 plays an important role in severe COVID-19. A change in IL-1 production may be associated with a mutation in the IL1Β gene. Our study analyzed the impact of the IL1Β gene variants (rs1143634) on disease progression in patients with severe COVID-19 pneumonia, taking into account treatment strategies. METHODS AND RESULTS: The study enrolled 117 patients with severe...

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PMID: 38720147
DOI: 10.1007/s11033-024-09569-4

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